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MTox700+ list of metabolic biomarkers of toxicity

Endogenous metabolite levels (or metabolic biomarkers) can describe the molecular phenotype of a cell or organism that is most downstream from chemical exposure. Consequently, changes in the levels of a set of metabolites can be used to predict the mode of action of a chemical, and in some cases it's adversity. Until now, toxicity-related metabolic biomarker resources have remained highly fragmented.

In 2020-21, funded by the European Chemicals Agency, our team conducted a large systematic review of multiple toxicological resources, generating a list of 722 metabolic biomarkers that have toxicological relevance. These were derived from multiple existing metabolite assays, databases and the scientific literature. This list of 722 metabolic biomarkers formed version 1.0 of the MTox700+ biomarker list, which was published in Toxicological Sciences.

The publicly available list of metabolic biomarkers can be downloaded below.

We welcome the submission of further toxicologically relevant biomarkers from the community to be considered for inclusion in a later release of MTox700+.